Ledermix Dental Paste
The opinions within this web page are not ours.Authors have been credited|
for the individual posts
where they are. - www.rxroots.com
Effect of immediate intracanal placement of Ledermix Paste(R) on
healing of replanted dog teeth after extended dry times.
Bryson EC, Levin L, Banchs F, Abbott PV, Trope M.
Department of Endodontics, School of Dentistry, UNC at Chapel Hill,
Chapel Hill, NC 27955, USA; Oral Health Centre of
WA and School of Dentistry, The University of Western Australia,
Ledermix Paste is a paste containing triamcinolone and demeclocycline
with demonstrated anti-inflammatory activity that may slow down resorptive
processes after severe traumatic injuries to the dentition. A total of
29 premolar roots of six mongrel dogs were extracted and instrumented
with rotary nickel titanium files. Fifteen of these roots were then
filled with a calcium hydroxide (Ca(OH)2) slurry and 14 roots were
filled with Ledermix Paste paste. All accesses were sealed with glass
ionomer and the roots replanted after an extraoral dry time of 60 min.
After 4 months, the dogs were killed and the roots prepared for
histological evaluation. Five-micrometer thick cross-sections of the
root and surrounding tissue taken every 90 micro m were evaluated for
healing. In addition, residual root mass was also measured to determine
the extent of root structure loss for each treatment method. The Ledermix
Paste-treated roots had statistically significantly more healing and less
resorption than the roots treated with Ca(OH)2. Root filling with
Ledermix Paste also resulted in significantly less loss in root mass due
to resorption compared to those roots filled with Ca(OH)2. Immediate
intracanal placement of Ledermix Paste at the emergency visit after an
avulsion injury appears to decrease resorption and increase favorable healing.
PMID: 12656865 [PubMed - indexed for MEDLINE]
A friend of mine asked if I knew of a local (USA) source for Ledermix paste.
I don't use it and I don't know if a U.S. or Canadian source exists.
He mentioned that the only place he can obtain it is from the UK.
Can anybody share a North American source if one exists. - Marc
Ledermix is probably not sold in North America at all. Dr. Pannkuk, on the
other side has a "Ledermix like" fluid prepared at his local pharmacy.- Thomas
Thomas:Do you have the ingredients as to what goes into it. We have an
excellent compounding pharmacy (reeds) out in Arizona who compounded the
triple antibiotic cocktail for deciduous teeth for me. I’m sure they could
handle this. Anyone know what goes into it, and the proportions?- Gary
Gary, Ledermix is composed of a steroid triamcinolone and antibiotic
demeclocycline. I don't know the proportions, but Terry may have an idea
as they make it for him in the USA - Thomas
Here’s what I have the pharmacy make up for me:
100ml of water
Marc,This answer I know.....Ledermix was developed back in the 60's....
the drug company that brought it to market decided the market was NOT
large enough to pour money into getting FDA approval....so alas...
it's neither marketed nor sold here in the US.
I called the company...actually made my way all the way up to a VP...
to see if this product could be sold in the US by them....and in a
nutshell...they won't do it unless they have enough evidence to
submit for an FDA approval.... cuz they ain't gonna put one dime
toward getting this approved.
They indicated they were willing to give exclusive marketing rights to
the company or individual willing to conquer this FDA problem....but I
decided it wasn't worth my effort....even though I have worked with
companies to get FDA 510K approval on devices...
On the other hand...if some of us would like to work together to see
if we could get this to market....then that would be great. - Joey D
or you get one of us guys in Europe to post it to you,it costs about
$40 a tube here and I posted some to md (name withheld to protect
innocent endodontists)in a simple envelope it comes in a single tube
a little bigger than eye ointment - Solly
Ledermix Dental Paste
Each gram (1gr) contains the active ingredients:
- Triamcinolone acetonide 10 mgrs
- Demeclocycline calcium equivalent Demeclocycline hidrochloride 30mgrs
Also contains: Sodium sulphite exsiccated (E221)
Do not store above 25ºC
Do not refrigerate
From Ledermix Face book page
Tips and Tricks: How do I use Ledermix? A typical situation:
Preparation work is done and the next day the patient
comes by to complain of pain. The examination shows nothing
conspicuous: the preparation wasn't even so extensive
as to be too near the pulpa, the temporary filling seems to be
tight and yet pain is reported.Gerhard Hetz
November 11, 2009 at 11:45pm
A main problem in endodontic cases are the acute pain which
the patient encouters as a result of pulpitis and pulpa
necrosis and apical periodontitis. Particularly the apical
periodontitis is responsible for paricular discomfort
as a simple measure such as the extirpation of the pulpa is
often not effective. Gerhard Hetz
November 11, 2009 at 11:45pm
|Ledermix: Ledermix is a corticosteroid-antibiotic paste or cement.
Medicaments such as Ledermix paste have been recommended as routine intra-canal medicaments.
Ledermix paste is an ideal medicament to be used as an initial dressing particularly
if the patient presents with endodontic symptoms
Quantity: Available in Paste and Cement Kits|