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Endo tips    Better Endo    Endo abstracts    Endo discussions

 Ledermix Dental Paste
The opinions within this web page are not ours.Authors have been credited
for the individual posts where they are. -

Ledermix: Ledermix is a corticosteroid-antibiotic paste or cement. Medicaments such as Ledermix paste have been recommended as routine intra-canal medicaments. Ledermix paste is an ideal medicament to be used as an initial dressing particularly if the patient presents with endodontic symptoms Quantity: Available in Paste and Cement Kits
Effect of immediate intracanal placement of Ledermix Paste(R) on healing of replanted dog teeth after extended dry times. Bryson EC, Levin L, Banchs F, Abbott PV, Trope M. Source Department of Endodontics, School of Dentistry, UNC at Chapel Hill, Chapel Hill, NC 27955, USA; Oral Health Centre of WA and School of Dentistry, The University of Western Australia, Perth, Australia. Abstract Ledermix Paste is a paste containing triamcinolone and demeclocycline with demonstrated anti-inflammatory activity that may slow down resorptive processes after severe traumatic injuries to the dentition. A total of 29 premolar roots of six mongrel dogs were extracted and instrumented with rotary nickel titanium files. Fifteen of these roots were then filled with a calcium hydroxide (Ca(OH)2) slurry and 14 roots were filled with Ledermix Paste paste. All accesses were sealed with glass ionomer and the roots replanted after an extraoral dry time of 60 min. After 4 months, the dogs were killed and the roots prepared for histological evaluation. Five-micrometer thick cross-sections of the root and surrounding tissue taken every 90 micro m were evaluated for healing. In addition, residual root mass was also measured to determine the extent of root structure loss for each treatment method. The Ledermix Paste-treated roots had statistically significantly more healing and less resorption than the roots treated with Ca(OH)2. Root filling with Ledermix Paste also resulted in significantly less loss in root mass due to resorption compared to those roots filled with Ca(OH)2. Immediate intracanal placement of Ledermix Paste at the emergency visit after an avulsion injury appears to decrease resorption and increase favorable healing. PMID: 12656865 [PubMed - indexed for MEDLINE] A friend of mine asked if I knew of a local (USA) source for Ledermix paste. I don't use it and I don't know if a U.S. or Canadian source exists. He mentioned that the only place he can obtain it is from the UK. Can anybody share a North American source if one exists. - Marc Ledermix is probably not sold in North America at all. Dr. Pannkuk, on the other side has a "Ledermix like" fluid prepared at his local pharmacy.- Thomas Thomas:Do you have the ingredients as to what goes into it. We have an excellent compounding pharmacy (reeds) out in Arizona who compounded the triple antibiotic cocktail for deciduous teeth for me. Im sure they could handle this. Anyone know what goes into it, and the proportions?- Gary Gary, Ledermix is composed of a steroid triamcinolone and antibiotic demeclocycline. I don't know the proportions, but Terry may have an idea as they make it for him in the USA - Thomas Heres what I have the pharmacy make up for me: Kenalog 10mg Demeclocycline 30mg 100ml of water - Terry Marc,This answer I know.....Ledermix was developed back in the 60's.... the drug company that brought it to market decided the market was NOT large enough to pour money into getting FDA alas... it's neither marketed nor sold here in the US. I called the company...actually made my way all the way up to a VP... to see if this product could be sold in the US by them....and in a nutshell...they won't do it unless they have enough evidence to submit for an FDA approval.... cuz they ain't gonna put one dime toward getting this approved. They indicated they were willing to give exclusive marketing rights to the company or individual willing to conquer this FDA problem....but I decided it wasn't worth my effort....even though I have worked with companies to get FDA 510K approval on devices... On the other hand...if some of us would like to work together to see if we could get this to market....then that would be great. - Joey D or you get one of us guys in Europe to post it to you,it costs about $40 a tube here and I posted some to md (name withheld to protect innocent endodontists)in a simple envelope it comes in a single tube a little bigger than eye ointment - Solly Ledermix Dental Paste Each gram (1gr) contains the active ingredients: - Triamcinolone acetonide 10 mgrs - Demeclocycline calcium equivalent Demeclocycline hidrochloride 30mgrs Also contains: Sodium sulphite exsiccated (E221) Do not store above 25C Do not refrigerate - Marcela From Ledermix Face book page Ledermix Tips and Tricks: How do I use Ledermix? A typical situation: Preparation work is done and the next day the patient comes by to complain of pain. The examination shows nothing conspicuous: the preparation wasn't even so extensive as to be too near the pulpa, the temporary filling seems to be tight and yet pain is reported.Gerhard Hetz November 11, 2009 at 11:45pm Ledermix A main problem in endodontic cases are the acute pain which the patient encouters as a result of pulpitis and pulpa necrosis and apical periodontitis. Particularly the apical periodontitis is responsible for paricular discomfort as a simple measure such as the extirpation of the pulpa is often not effective. Gerhard Hetz November 11, 2009 at 11:45pm
1 visit lateral incisior

Coagulum over implant

Trauma- Endo-Surgery

Pre bent SS hand files

Isolation for post buildup

Placing MTA retrofill

Horizontal percussion

Calcified central incisor

Temporary glass ionomer

Irreversible pulpitis

Ortho and retrograde

coronal restoration

Cervical hypersensitivity

23 year recall

A gone case

Weird lesion

Huge lesion

Pulpitis on 45

Isthmus anatomy

14 year recall

Caries exposure

Tooth #37

Perio inflammation

Severe percussion

2 D healing

Crown access

Canal with acute bend

Cracked tooth syndrome

Tooth discolorisation

Mesial systems with POE

Endo treatment

Newsletter 30th May 2010

Endo implant

To CT or not

Buccal gingival swelling

Polished collar

Molar restoration

Immediate implant

Whiteline puzzle

Final coronal preparation

Type 3 Heithersay resorption

19 year recall - Molar case

Isthmus Anatomy

Acute irrversible pulpitis

Horizonatal,vertical percussion

Orthoband cases

Symmetric resorption

Removing Niti instruments

Calcified incisor

Ca(OH)2 extrusion

Resorption defect

Apico on MTA